DES Info: Latent health effect of DES exposure

[KMFDallas]

DES Info: Latent health effect of DES exposure

Latent health effects in DES-exposed offspring provide strong evidence for study regarding the fetal basis of adult disease.

The developing fetus is uniquely susceptible to latent health effects due to the several underdeveloped systems at birth (i.e., DNA repair mechanisms, liver metabolism, blood/brain barrier, and immune system). Therefore, low doses of chemicals thought to be safe for use in pregnant women may seriously impact the adult health of their offspring.

The data on DES have shown that dose and timing of exposure may matter –cumulative dose, time since exposure, or age at diagnosis of disease are considered important variables in cohort data analyses.

The DES Tragedy continues…….

NIH

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