Historically, the pregnancy dosage recommendations began at five milligrams and increased to over one hundred milligrams per day.
For purposes of illustration, comparing the current dosage of estrogen in a birth control pill with DES, a pregnant woman on DES was ingesting the estrogenic equivalent of hundreds of birth control pills daily.
A child in utero would essentially be bathed in estrogen. At those doses, its developing estrogen-sensitive reproductive organs in their embryonic formation would be over-stimulated and malformed by the excess of hormones!
The DES Tragedy continues today and is now being seen in the grandchildren – 3rd generation!