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DES Info: DES Daughters with higher risk for breast cancer, infe

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DES bottles 3.jpgA drug that millions of pregnant women took decades ago to prevent miscarriage and complications has put their daughters at higher risk for breast cancer and other health problems that are showing up now, a new federal study finds. This study suggests that infertility is twice as common and that breast cancer risk is nearly doubled in these daughters. 
"There's no knowing what's going to happen as we age. There's always the fear there's going to be another cancer or another outcome," she said. "I don't think I'll ever get to the point where I feel it's behind me."
 The sons of DES users also face health risks — testicular problems and cysts — but these are less well studied and don't seem to be as common. Even less is known about the third generation — "DES grandchildren." Some research suggests these girls start menstruating late and have irregular periods, possible signs of fertility issues down the road.
"We don't want to cause a panic of everyone rushing out thinking they're going to get cervical or breast cancer. They just need to have that conversation with their physician," said Dr. Sharmila Makhija, women's health chief at the University of Louisville.
The average woman has about a 1 in 50 chance of developing breast cancer by age 55; for DES daughters it's 1 in 25, the study found. 
DES, or diethylstilbestrol, was widely used in the United States, Europe and elsewhere from the 1940s and into the 1970s to prevent miscarriage, premature birth, bleeding and other problems. Many companies made and sold it as pills, creams and other forms.
Studies later showed it didn't work. The government told doctors to stop using it in pregnancy in 1971, after DES daughters in their late teens and 20s were found to be at higher risk of a rare form of vaginal cancer. Further research has tied DES to infertility and various pregnancy problems.
"They've been identified one at a time. Nobody's been able to get the whole picture," said Dr. Robert Hoover, a researcher at the National Cancer Institute. The new study, which he led, "takes the woman and looks at everything that can happen as a result of this drug," and adds evidence for some previously suspected risks like breast cancer, he said.
The study started in 1992 and involved about 4,600 DES daughters and a comparison group of 1,900 similar women whose mothers had not used DES. Their health was tracked over time through surveys and medical records. Their average age at the last follow-up was 48.
In the study, researchers found these rates of health problems in DES daughters compared to non-exposed women:
—Breast cancer, 3.9 percent versus 2.2 percent.
—Cervical pre-cancer, 6.9 percent versus 3.4 percent.
—Infertility, 33.3 percent versus 15.5 percent.
—Early menopause, 5.1 percent versus 1.7 percent
These complications were seen among women who were able to become pregnant:
—Preterm delivery, 53.3 percent versus 17.8 percent.
—Miscarriage, 50.3 percent versus 38.6 percent.
—Tubal pregnancy, 14.6 percent versus 2.9 percent.
—Stillbirth, 8.9 percent versus 2.6 percent.
—Preeclampsia (high blood pressure during pregnancy), 26.4 percent versus 13.7 percent.
The claim of added breast cancer risk is being tested by 53 women in a lawsuit against DES makers under way now in Boston. One of them is Jackie White, 48, who lives in Centerburg, Ohio, north of Columbus. She said she had a misshaped uterus and reproductive problems, and found a lump last year that turned out to be breast cancer. Tests showed 20 tumors in one breast, two pre-cancers in the other and spread to her lymph nodes. "I ate a low-fat diet. I exercise faithfully so I was not overweight. I had none of the normal risk factors," she said.
DES exposure needs to be considered with the whole picture of a woman's risk, said Dr. G. Wright Bates, director of reproductive medicine at the University of Alabama at Birmingham. "In some cases, frequent Pap smears and early mammography or breast MRI may be warranted for women with DES exposure," he said. Others are focused on possible risks to the next generation.
Thursday, October 6, 2011
Karen M. Fernandes
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